Should I start SF or IND defense for week 2?

WHAAAT? 49ers defense is NOT that BAD! Look at the stats for number of sacks. They did play poorly against the Seahawks... So, did colts in week one! They allowed over 200 rushing yards and 3 rushing TDs for Arian Foster. I would pick Colts' defense against Giants, because Drew Brees can pick the best defense apart.